Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark. Department of Intensive Care, Randers Hospital, Randers, Denmark. Department of Intensive Care, Aalborg University Hospital, Aalborg, Denmark. Department of Intensive Care, Herning Hospital, Herning, Denmark. Department of Intensive Care, Helsinki University Hospital, Helsinki, Finland. Department of Intensive Care, Holbæk Hospital, Holbæk, Denmark. Department of Intensive Care, Holstebro Hospital, Holstebro, Denmark. Department of Intensive Care, Nordsjællands Hospital, Hillerød, Denmark. Department of Intensive Care, Herlev Hospital, Herlev Municipality, Denmark. Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark. anders.perner@regionh.dk. Centre for Research in Intensive Care, Copenhagen, Denmark. anders.perner@regionh.dk.